Chimeric Antigen Receptor T-Cell Immunotherapy Tackles Blood Cancers
نویسندگان
چکیده
منابع مشابه
Chimeric antigen receptor T-cell immunotherapy tackles blood cancers.
intervention studies, assess change, and establish relationships with theoretically relevant factors and clinically important outcomes such as mortality. " The instrument has a broad content coverage, [has] very high reliability, and is strongly linked to self-confidence about engaging in health decisions, " Dumenci said. Completing CHLT-30 takes 10–15 minutes , and the score reflects the numbe...
متن کاملAdvancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects
Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...
متن کاملChimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer
CD4+ and CD8+ T lymphocytes are powerful components of adaptive immunity, which essentially contribute to the elimination of tumors. Due to their cytotoxic capacity, T cells emerged as attractive candidates for specific immunotherapy of cancer. A promising approach is the genetic modification of T cells with chimeric antigen receptors (CARs). First generation CARs consist of a binding moiety sp...
متن کاملChimeric Antigen Receptor (CAR) T-Cell Therapy.
Surgery, chemotherapy, and radiation therapy have been the foundation of cancer treatment. Advances in the field of immunology (a branch of science that studies all aspects of the immune system) have led to a greater understanding of the ways in which the body’s own defenses can be used for treatment of blood cancers. Cancer researchers are now studying how the immune system can help destroy ca...
متن کاملChimeric Antigen Receptor T Cell Therapy in Hematology
It is well demonstrated that the immune system can control and eliminate cancer cells. Immune-mediated elimination of tumor cells has been discovered and is the basis of both cancer vaccines and cellular therapies including hematopoietic stem cell transplantation. Adoptive T cell transfer has been improved to be more specific and potent and to cause less off-target toxicity. Currently, there ar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2015
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djv112